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Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
485
Issue
3
Identifiers
DOI: 10.1016/j.neulet.2010.08.078
Keywords
  • Swimming
  • Central Pattern Generator
  • Intersegmental Coordination
  • Medicinal Leech
  • Hirudo Verbana

Abstract

Abstract Medicinal leeches ( Hirudo spp.) swim using a metachronal, front-to-back undulation. The behavior is generated by central pattern generators (CPGs) distributed along the animal's midbody ganglia and is coordinated by both central and peripheral mechanisms. Here we report that a component of the venom of Conus imperialis, α-conotoxin ImI, known to block nicotinic acetyl-choline receptors in other species, disrupts swimming. Leeches injected with the toxin swam in circles with exaggerated dorsoventral bends and reduced forward velocity. Fictive swimming in isolated nerve cords was even more strongly disrupted, indicating that the toxin targets the CPGs and central coordination, while peripheral coordination partially rescues the behavior in intact animals.

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