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Adhesion of multiple myeloma cells to the bone marrow microenvironment: implications for future therapeutic strategies

Authors
Journal
Molecular Medicine Today
1357-4310
Publisher
Elsevier
Publication Date
Volume
2
Issue
10
Identifiers
DOI: 10.1016/1357-4310(96)84846-5
Disciplines
  • Biology

Abstract

Abstract Multiple myeloma is characterized by excess plasma cells within the bone marrow in association with monoclonal antibody protein in the serum and/or urine. Tumor cells localize within the marrow via an interaction of cell-surface adhesion molecules with their respective ligands on marrow stromal cells and extracellular matrix proteins. Stimulation of myeloma cells via these cell-surface molecules, either directly or via tumor cell adhesion to stromal cells, can induce autocrine or paracrine tumor cell growth mediated by interleukin 6. It might therefore be possible to develop innovative treatment strategies either to inhibit interleukin 6 production or to interrupt interleukin 6 signal transduction in multiple myeloma.

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