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A recyclable non-immobilized siloxy serine organocatalyst for the asymmetric direct aldol reaction

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
49
Issue
27
Identifiers
DOI: 10.1016/j.tetlet.2008.04.159
Keywords
  • Direct Asymmetric Aldol
  • Ionic Liquid
  • Organocatalyst
  • Recyclable

Abstract

Graphical abstract A recyclable siloxy- l-serine organocatalyst has been developed to catalyze asymmetric direct aldol reactions in [bmim][BF 4], furnishing the β-hydroxy carbonyl scaffold in high enantio- and diastereoselectivities using a selection of aromatic aldehydes and cycloalkanes. The siloxy serine organocatalyst in the ionic liquid can be reused for up to four successive cycles with comparable enantioselectivities.

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