Affordable Access

Publisher Website

The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats

Authors
Journal
Behavioural Brain Research
0166-4328
Publisher
Elsevier
Publication Date
Volume
226
Issue
1
Identifiers
DOI: 10.1016/j.bbr.2011.09.027
Keywords
  • Exercise
  • Aging
  • Neurotrophic Factors
  • Hypoglossal Nucleus
  • Tongue Muscle
  • Swallowing
Disciplines
  • History

Abstract

Abstract Age-associated changes in tongue musculature may contribute to dysphagia. One possible treatment is tongue exercise. Exercise induces synaptic plasticity by increasing neurotrophic factors in spinal cord and limb musculature. However, effects of exercise on neurotrophic factors in the cranial sensorimotor system are unknown. Our purpose was to examine the effects of age and exercise on brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the rat hypoglossal nucleus. Young, middle-aged, and old rats were assigned to exercise or no-exercise control conditions. Exercise animals were trained to perform a tongue press task for 8 weeks. Samples from the hypoglossal nucleus were analyzed for BDNF and TrkB immunoreactivity. Baseline maximum tongue forces were similar in all age groups and increased significantly following exercise. BDNF immunoreactivity did not show a significant decrease with age in control group. However, in the exercise group, BDNF was significantly increased in young animals. TrkB immunoreactivity decreased significantly with age in control group, but did not change with exercise. BDNF and TrkB immunoreactivity levels were positively correlated with exercise in young and middle aged animals, but were negatively or weakly correlated with exercise in old animals and with a lack of exercise in no-exercise controls. Tongue exercise was associated with increased tongue forces in rats at all ages. While increases in BDNF and TrkB levels associated with exercise may play a role in mechanisms contributing to increased tongue forces in young and middle-aged rats, other mechanisms may be involved in increased tongue forces observed in old rats.

There are no comments yet on this publication. Be the first to share your thoughts.