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Venous Thromboembolism and Mortality Associated With Tranexamic Acid Use During Total Hip and Knee Arthroplasty

The Journal of Arthroplasty
DOI: 10.1016/j.arth.2014.08.022
  • Tranexamic Acid
  • Knee Arthroplasty
  • Venothromboembolism
  • Hip Arthroplasty
  • Mortality


Abstract TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR=0.98; 95% CI 0.67-1.45; P=0.939) or adjusted odds of death (OR=0.26; 95% CI 0.04-1.80; P=0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.

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