Affordable Access

Publisher Website

Long-term survival of a patient with bone marrow gelatinous degeneration of idiopathic origin

Authors
Journal
The Korean Journal of Hematology
1738-7949
Publisher
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis (KAMJE)
Publication Date
Volume
47
Issue
4
Identifiers
DOI: 10.5045/kjh.2012.47.4.309
Source
Legacy
Keywords
  • Letter To The Editor
Disciplines
  • Medicine

Abstract

untitled 309 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. Serous atrophy in a diffuse and severe hypocellular background (A). Reduced fat cells, a diffuse extracellular gelatinous amorphous material, small typical lymphocytes, and mature plasma cells were also observed (B). Small islets of hematopoietic cells were detected at a level of <5%. http://dx.doi.org/10.5045/kjh.2012.47.4.309 The Korean Journal of Hematology Volume 47ㆍNumber 4ㆍDecember 2012 Letter to the Editor Long-term survival of a patient with bone marrow gelatinous degeneration of idiopathic ori- gin TO THE EDITOR: Gelatinous bone marrow transformation (GMT) is a rare bone marrow (BM) disorder of unknown pathogenesis. It is characterized by fat cell atrophy, focal loss of hematopoietic cells, and deposition of extracellular gelatinous substances (mucopolysaccharides rich in hyalur- onic acid) [1]. The pathogenesis of GMT involves the deposi- tion of hyaluronic acid, which hampers hematopoiesis by altering the BM microenvironment and stroma and dis- ruption of the interactions between BM cells and cell signal- ing molecules [1]. GMT has been reported in association with chronic debilitating diseases, such as anorexia nervosa, malnutrition, and human immunodeficiency virus (HIV) infection, and after cytotoxic treatments [2]; in addition, GMT has been described in patients with myelodysplastic syndrome [3], acute myeloblastic leukemia [3], and idio- pathic myelofibrosis [4]. However, idiopathic GMT has also been reported [5]. Herein, we report a case of idiopathic GMT in a patient who had an unusual clinical course and long-term survival. The patient was a 64-year-old Caribbean woman who had been living in Rome for more than 30 years. She

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F