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Long-term survival of a patient with bone marrow gelatinous degeneration of idiopathic origin

The Korean Journal of Hematology
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis (KAMJE)
Publication Date
DOI: 10.5045/kjh.2012.47.4.309
  • Letter To The Editor
  • Medicine


untitled 309 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. Serous atrophy in a diffuse and severe hypocellular background (A). Reduced fat cells, a diffuse extracellular gelatinous amorphous material, small typical lymphocytes, and mature plasma cells were also observed (B). Small islets of hematopoietic cells were detected at a level of <5%. The Korean Journal of Hematology Volume 47ㆍNumber 4ㆍDecember 2012 Letter to the Editor Long-term survival of a patient with bone marrow gelatinous degeneration of idiopathic ori- gin TO THE EDITOR: Gelatinous bone marrow transformation (GMT) is a rare bone marrow (BM) disorder of unknown pathogenesis. It is characterized by fat cell atrophy, focal loss of hematopoietic cells, and deposition of extracellular gelatinous substances (mucopolysaccharides rich in hyalur- onic acid) [1]. The pathogenesis of GMT involves the deposi- tion of hyaluronic acid, which hampers hematopoiesis by altering the BM microenvironment and stroma and dis- ruption of the interactions between BM cells and cell signal- ing molecules [1]. GMT has been reported in association with chronic debilitating diseases, such as anorexia nervosa, malnutrition, and human immunodeficiency virus (HIV) infection, and after cytotoxic treatments [2]; in addition, GMT has been described in patients with myelodysplastic syndrome [3], acute myeloblastic leukemia [3], and idio- pathic myelofibrosis [4]. However, idiopathic GMT has also been reported [5]. Herein, we report a case of idiopathic GMT in a patient who had an unusual clinical course and long-term survival. The patient was a 64-year-old Caribbean woman who had been living in Rome for more than 30 years. She

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