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Developmental origins of adult diseases

Authors
Journal
Indian Journal of Endocrinology and Metabolism
2230-8210
Publisher
Medknow Publications
Publication Date
Volume
16
Issue
4
Identifiers
DOI: 10.4103/2230-8210.98005
Keywords
  • Review Article
Disciplines
  • Biology
  • Computer Science
  • Ecology
  • Geography
  • Medicine

Abstract

There is considerable evidence for the fact that early life environment in human beings are associated with future development of various metabolic diseases. Fetal programming and perinatal events appear to exert effects on later life that are independent of environmental risk factors in adults. Our understanding of the underlying mechanisms are limited and remains unclear. However several animal models and epidemiological studies have shown this association, and it is assumed secondary to the penalties of developmental plasticity. In this review, we amalgamate facts from several disciplines to support this hypothesis.

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