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Structure and Function of a Sea Urchin Orthodenticle-Related Gene (HpOtx)

Authors
Journal
Developmental Biology
0012-1606
Publisher
Elsevier
Publication Date
Volume
193
Issue
2
Identifiers
DOI: 10.1006/dbio.1997.8802
Disciplines
  • Biology

Abstract

Abstract Two distinct types of orthodenticle-related proteins (HpOtx E/L) have been implicated as transcription activators of the aboral ectoderm-specific arylsulfatase ( Ars) gene. Here, we describe the structure of HpOtx gene and present evidence that mRNAs of HpOtx E/Lare transcribed from a single HpOtx gene by altering the transcription start site and by alternative splicing. By transactivation experiments, we have also demonstrated that HpOtx Lactivates the Arspromoter in the gastrula-stage embryo.

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