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Regulation of aspartate transcarbamoylase activity inPseudomonas stutzeri

Authors
Journal
Microbiological Research
0944-5013
Publisher
Elsevier
Publication Date
Volume
152
Issue
4
Identifiers
DOI: 10.1016/s0944-5013(97)80054-7
Keywords
  • Pseudomonas Stutzeri
  • Aspartate Transcarbamoylase
  • Inhibition
  • Ribonucleotides
  • Pyrophosphate
Disciplines
  • Biology

Abstract

Abstract The regulation of aspartate transcarbamoylase activity in crude extracts of the denitrifying bacterium Pseudomonas stutzeri ATCC 17588 was investigated. Under saturating substrate concentrations, putative effectors of this bacterial transcarbamoylase activity were screened at two concentrations and were found to negatively control its activity. Both phosphate and pyrophosphate were strongly inhibitory to the P. stutzeri transcarbamoylase activity. Of the ribonucleotides tested as effectors, it was observed that ATP, UTP and GTP produced the greatest enzyme inhibition.

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