Affordable Access

Publisher Website

Methylenedioxymethamphetamine's capacity to establish place preferences and modify intake of an alcoholic beverage

Pharmacology Biochemistry and Behavior
Publication Date
DOI: 10.1016/0091-3057(90)90538-s
  • Mdma
  • Methylenedioxymethamphetamine
  • Positive Affect
  • Conditioned Place Preference
  • Ethanol Intake
  • Drugs Of Abuse


Abstract Doses of 0.2, 2.0, 6.3 and 20.0 mg/kg 3,4-methylenedioxymethamphetamine (MDMA), a putative neurotoxin at serotonergic neurons and a recreational drug, were assessed using Sprague-Dawley rats in the conditioned place preference (CPP) test. Also, the drug's effects on intake of a sweetened ethanol solution (ES) was assessed. The CPP testing involved multiple administrations of MDMA with frequent periodic testing (weekly for 4 weeks) of MDMA's effects. Doses of 2.0 and 6.3 mg/kg produced positive CPPs with every test. MDMA also affected rat's gain in body weight across the 4 weeks of dosing. The 2.0 mg/kg dose reliably incremented gain in body weight, while the 20.0 mg/kg dose reliably attenuated it. In the drinking experiment, water-deprived rats (22 h/day) were given daily oppurtunities to drink either tap water or a sweetened ES. When stable intakes were achieved, MDMA's effects were assessed across repeated daily administrations (12 days) and subsequently (16 days). MDMA, dose-relatedly, decreased intake of both ES and water with the highest dose leading to marked loss in body weight. Intakes of fluids were not modified markedly subsequent to dosing. In summary, MDMA is an agent that produces a positive CPP (providing further evidence for MDMA's abuse liability), produces changes in weight gain and nonselectively reduces fluid intake among fluid-deprived rats.

There are no comments yet on this publication. Be the first to share your thoughts.