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Turning the tumor microenvironment into a self vaccine site

Authors
Journal
OncoImmunology
2162-4011
Publisher
Landes Bioscience
Publication Date
Volume
1
Issue
6
Identifiers
DOI: 10.4161/onci.20238
Keywords
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Abstract

We aimed to determine if the tumor microenvironment could be turned into a “self”-vaccine site. We show that provoking a local inflammatory response modulates endothelia to permit the infiltration of innate and adaptive effector cells which collaborate to eradicate the inflamed tumor and other tumor deposits, and provide long-term protection.

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