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Spatial confinement can lead to increased stability of amorphous indomethacin

Authors
Publisher
Elsevier BV
Publication Date
Source
Legacy
Keywords
  • The Aim Of This Study Was To Investigate Whether The Physical Stability Of Amorphous Indomethacin Ca
  • Crystallisation From The Spatially Confined Amorphous Indomethacin In The Microcontainers Was Determ
  • Amorphous Indomethacin In Both A Bulk Form And Contained Within Microcontainers Was Prepared By Melt
  • Respectively
  • Followed By Quench-Cooling
  • Microcontainers Of Three Different Sizes (Diameters Of 73μM
  • 174μM And 223μM) Were Used For The Confinement Of Amorphous Indomethacin
  • In Order To Elucidate Whether The Size Of The Microcontainer Had An Influence On The Stability Of Th
  • Following Preparation
  • All Samples Were Stored At 30°C And 23% Rh
  • A Sample Of 100 Microcontainers Of Each Size Was Selected And Measured On A Raman Microscope Over A
  • Over Time
  • A Crystallisation Number Was Obtained For The Amorphous Indomethacin In The Microcontainers
  • The Crystallisation Numbers From The Microcontainers Were Compared With The Crystallisation Kinetics
  • As Determined By Ft-Raman Spectroscopy
  • Comparison Of The Numeric Crystallisation In The Microcontainers With The Crystallisation Kinetics O
  • In The 174μM Microcontainers
  • 29
  • 0±2
  • 6% Of The Amorphous Indomethacin Crystallised To The Stable γ-Form Over A Period Of 30Days
  • Whilst 38
  • 3±1
  • 5% Of The Amorphous Indomethacin Crystallised In The 223μM Microcontainers
  • Both These Values Were Significantly Different From That Observed In The Amorphous Bulk Indomethacin
  • Where 51
  • 0% Crystallised To The γ-Form After 30Days
  • Comparing The 174 And 223μM Microcontainers Also Revealed A Significantly Greater Stabilising Effect
  • 0061)
  • Surprisingly
  • For Microcontainers With An Inner Diameter Of 73μM
  • No Stability Improvement Was Found When Compared To Amorphous Bulk Indomethacin
  • It Was Observed That The Amorphous Indomethacin Within These Containers Converted To The α-Form Of I
Disciplines
  • Pharmacology

Abstract

Spatial confinement can lead to increased stability of amorphous indomethacin - DTU Orbit (25/04/14) Spatial confinement can lead to increased stability of amorphous indomethacin - DTU Orbit (25/04/14) Spatial confinement can lead to increased stability of amorphous indomethacin Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, T. & Müllertz, A. 2012 In : European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 418-425 Publication: Research - peer-review › Journal article – Annual report year: 2012

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