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Reproductive toxicology. Ethylene glycol monoethyl ether (2-ethoxyethanol).

Environmental Health Perspectives
Environmental Health Perspectives
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  • Research Article
  • Chemistry
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Ethylene Glycol Monoethyl Ether (2-Ethoxyethanol) CAS #1 10-80-5 Swiss CD-1 mice, at 0.0, 0.5, 1.0,2.0%, drinking water James C. Lamb IV, NTP/NIEHS Project Officer Dushyant K. Gulati, Leta M. Hommel, K. B. Poonacha, Environmental Health Research and Testing Started 7/9/82; Completed 5/14184 NTIS: PB851 18651 H H H H H-O-C-C-0-C-C-H H H H H Ethylene glycol monoethyl ether (EGEE), a common chemical and solvent used in industry and in consumer goods, was tested for reproductive toxicity in Swiss CD-1 mice using the RACB protocol (Lamb et al., Environ Health Perspect 57:85-90 [1984]). It was part of a series of glycol ethers and congeners evaluated for structure-activity correlations using this design. Data collected on body weights, clinical signs, and food and water consumption during the dose- range-finding segment (Task 1) were used to set concentrations for the main study (Task 2) at 0.5, 1.0, and 2.0% weight per volume EGEE in drinking water. These concentrations produced calculated con- sumption estimates of approximately 0.76, 1.50, and 2.6 g/kg/day. There were no effects on body weights during the continuous cohabitation por- tion of the study. Two females died in both the control and high dose groups. Water consumption was unchanged by the addition ofEGEE. No pairs in the 2% EGEE group had any litters of pups, live or dead. In the middle dose group (1% EGEE), the num- ber of litters per fertile pair was reduced by 35%, there were approximately 2.6 live pups per litter versus a control mean of 9.8, the proportion of pups born alive was reduced by 50%, and the weight of the live pups, adjusted for litter size, was reduced by 12%. The fertility indices in the low dose (0.5% EGEE) were not affected. Task 3 crossover mating trials were conducted with the controls and both the 2% EGEE and 1% EGEE groups. With the 2% EGEE mice, no litters were delivered of treated females mated with control males, while 5 of 18 control females delivered a litter after mating with a treated male (significa

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