Affordable Access

Publisher Website

In vitro biosynthesis by articular chondrocytes of a specific low molecular size proteoglycan pool

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
153
Issue
1
Identifiers
DOI: 10.1016/0014-5793(83)80145-8
Keywords
  • Proteoglycan
  • Sulphation
  • Chondrocyte

Abstract

Abstract Proteoglycans synthesized by articular and epiphyseal chondrocytes in culture were compared. Proteoglycans extruded by the two types of cells into the culture medium are of identical M r. On the other hand, the proteoglycans of cells or pericellular matrix synthesized by the articular chondrocytes are characterized by an heterogeneous fraction of low- M r which is not present in the material derived from epiphyseal chondrocytes. There are at least two components in this fraction: the first seems to be a precursor of aggregated proteoglycans, the other may represent a component of cell coat. Stimulation of the cell cultures with vitamin D metabolites and somatomedin enhances proteoglycan biosynthesis but no modification is observed in the proteoglycan M r.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The in vitro cell culture age and cell density of...

on Journal of Cellular Physiology December 1984

Polysulphated polysaccharides: an in vitro study o...

on Archives internationales de ph... August 1986

Effect of static compression on proteoglycan biosy...

on Journal of orthopaedic researc... September 1998
More articles like this..