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A new sulfated β-galactan from clams with anti-HIV activity

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
321
Identifiers
DOI: 10.1016/s0008-6215(99)00188-3
Keywords
  • Clam Polysaccharide
  • β-(1→3)-Linked Galactan Sulfate
  • Anti-Hiv Activity

Abstract

Abstract A new polysaccharide composed of galactan sulfate with a β-(1→3)-glycosidic linkage has been isolated from the marine clam species Meretrix petechialis. The polysaccharide was homogeneous in its composition containing d-galactose. The glycosidic linkage was examined by 2D DQF-COSY and 2D NOESY spectroscopy. The coupling constant of anomeric proton was 7.8 Hz, suggesting a β-galacto configuration. The downfield shift of H-2 of galactose residue demonstrated the presence of 2- O-sulfonate group. TQF-COSY confirmed that the C-6 position was substituted with a sulfonate group. The anti-HIV activity of the polysaccharides has been evaluated by the inhibition of syncytia formation. The fusion index and percentage fusion inhibition of sulfated galactan were 0.34 and 56% at 200 μg/mL.

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