Affordable Access

Publisher Website

Immunization of susceptible BALB/c mice againstLeishmania braziliensis,:II. Use of temperature-sensitive avirulent clones of parasite for vaccination purposes

Authors
Journal
Cellular Immunology
0008-8749
Publisher
Elsevier
Publication Date
Volume
94
Issue
1
Identifiers
DOI: 10.1016/0008-8749(85)90081-4

Abstract

Abstract Avirulent clones of Leishmania braziliensis were produced by treatment of parental parasite stock with the mutagen N-methyl- N′-methyl- N′-nitro- N-nitrosoguanidine and selection for growth at 19 °C. These clones have a clear preference for infection and growth in vitro at 19 °C rather than the normal 28 °C. In addition, they can be used to vaccinate naive mice successfully against growth of the parental parasite clones. Immunity can be adoptively transferred from vaccinated mice by Lyt-1 + cells from immunized animals.

There are no comments yet on this publication. Be the first to share your thoughts.