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Some aspects of tyrosine secondary metabolism

Authors
Journal
Biochemical Pharmacology
0006-2952
Publisher
Elsevier
Publication Date
Volume
56
Issue
9
Identifiers
DOI: 10.1016/s0006-2952(98)00170-1
Keywords
  • Dopa
  • Dopamine
  • Topa
  • Topamine
  • Metabolism
  • Neurotoxicity
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract The origin and fate of some tyrosine secondary metabolites within specialized eukaryotic cells are discussed in the light of our knowledge of the plasma environment to which they are exposed throughout their lifetime. Attention is focused on ar-dihydroxy and -trihydroxy derivatives and the corresponding quinoidal counterparts, as well as on the enzymic activities involved in the formation and degradation of these potentially toxic molecules. Some physiopathological and pharmacological implications of the above-mentioned topics are considered, taking into account the well known toxicity of reactive intermediates in molecular oxygen reduction, as well as the reactivity of both semiquinonic and quinonic products of catecholamine oxidation.

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