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Precultured and fresh human T-cells suppress the mitogen response of autologous lymphocytes

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
6
Issue
2
Identifiers
DOI: 10.1016/0165-2478(83)90088-3

Abstract

Abstract Human T-lymphocytes, after culture at 37°C for 48 h, suppressed the Con A-induced blastogenesis of fresh autologous lymphocytes. Both Fc γ receptor- positive and -negative T-cell subsets were active as suppressors. Non-T-cells failed to show such a phenomenon. Similarly, freshly isolated T-cells, and Fc γ receptor-positive T-lymphocytes also suppressed the blastogenic response. Thus, preculture is not required to obtain “suppressor cells”. The suppression of mitogen responses therefore seems to be an inherent property of T-cells.

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