Affordable Access

Publisher Website

A method for monitoring the effectiveness of allopurinol pretreatment in the prevention of ischemic/reperfusion injury

Authors
Journal
Journal of Pharmacological Methods
0160-5402
Publisher
Elsevier
Publication Date
Volume
22
Issue
4
Identifiers
DOI: 10.1016/0160-5402(89)90008-9
Keywords
  • Allopurinol
  • Red Cell Lipid Peroxidation
  • Heart-Lung Transplantation
  • Ischemic/Reperfusion Injury
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract The protective actions of allopurinol in ischemic/reperfusion injury seem critically determined by the drug pretreatment regimen and may involve generalized alterations in tissue antioxidant status. In the present study, 12 male swine to be used as donors and recipients in a heart-lung transplantation study were treated with allopurinol given orally at a dose of 50 mg kg for 4 days prior to surgery. Red cells from allopurinol-treated animals showed a progressive decrease in susceptibility to in vitro peroxidative challenge. Although the degree and time-course of protection showed some degree of interanimal variation, maximal effects were obtained in most animals after 2–3 days. The extent of red cell protection in both donor and recipient animals correlated significantly with the functional viability of the transplanted lung, as assessed by tissue water content. It is suggested that the susceptibility of red cells to in vitro oxidative damage may provide a useful functional assessment of generalized alterations in antioxidant status produced by pharmacological interventions.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A method for monitoring the effectiveness of allop...

on Journal of pharmacological met... December 1989

Prevention of reperfusion injury in ischemic-reper...

on Transplant international : off... December 1989

Pretreatment with allopurinol in cardiac hypoxic-i...

on Basic research in cardiology February 1999

Prevention of deleterious effects of reperfusion i...

on Digestive Diseases and Science... February 2001
More articles like this..