The accomplishments and progress that have occurred over the past 20 years in collaborative filariasis research between NAMRU-2 detachment staff, National Institute of Health, Research and Development (NIHRD), and Directorate General of Communicable Disease Control and Environmental Health (CDC&EH), University of Indonesia, and other health institutions have produced an impressive array of important contributions to the study of human lymphatic filarial disease. Over this time, no less than 62 publications specifically addressing filariasis studies have come about as a direct result of close cooperation between interorganizational investigators (Figs. 1,2). Beginning in 1972 with observations on diethylcarbamazine (DEC) provocation for diurnal diagnosis of W. bancrofti, publications have covered a wide range of different disciplines all with the common goal of understanding and ultimately controlling this disease. Numerous biomedical and filariasis surveys have been recorded over this period, adding greatly to our knowledge of the diverse epidemiology and disease distribution across the archipelago. The following is an attempt to highlight the major milestones among selected categories that have made significant contributions and have provided insights into filariasis research.