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Inhibition of sperm glutathioneS-transferase leads to functional impairment due to membrane damage

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
422
Issue
3
Identifiers
DOI: 10.1016/s0014-5793(98)00032-5
Keywords
  • Sperm
  • Glutathiones-Transferase
  • Fertilization
  • Motility
  • Lipid Peroxidation

Abstract

Abstract The role of glutathione S-transferase (GST) in the defense mechanisms of sperm is not known. We report here interference with normal motility, acrosome reaction and fertilizing ability of the goat sperm as a consequence of inhibition of GST activity. That these functional impairments were due to membrane changes was evident from the alteration in the lipid peroxidation status of these cells after GST inhibitor treatment. Increased reactive oxygen species production by the cell which occurred when GST activity was suppressed may be the mediator for membrane damage. The data argue for a role of GST in maintaining sperm membrane status.

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