Affordable Access

Publisher Website

Why did the acquired immune system of vertebrates evolve?

Authors
Journal
Developmental & Comparative Immunology
0145-305X
Publisher
Elsevier
Publication Date
Volume
31
Issue
5
Identifiers
DOI: 10.1016/j.dci.2006.08.009
Keywords
  • Evolution
  • Selection
  • Acquired Immune System
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Rapidly expanding genomic information offers important insights into the mechanisms of acquired immunity and has fostered progress in comparative immunology. However, the question of why the acquired immune system, a trait restricted to jawed vertebrates, evolved has rarely been addressed. Here, I will examine three unique features of early vertebrate evolution, during the 50 million years when the acquired immune system evolved: co-evolution with specialised parasites, increased metabolic rates and genomic instability. These combine to shape a powerful multi-level and multi-causal selective scenario that I propose could have moulded the acquired immune system.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Why did the acquired immune system of vertebrates...

on Developmental & Comparative Im... 2007

How did our complex immune system evolve?

on Nat Rev Immunol January 2010

Did the molecules of adaptive immunity evolve from...

on Integrative and comparative bi... April 2003
More articles like this..