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Blockers of potassium current and resting membrane potential in rat muscle fibers

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
51
Issue
3
Identifiers
DOI: 10.1016/0024-3205(92)90080-9

Abstract

Abstract Rat diaphragm fibers were equilibrated for several hours in 150 mM KCl; when they were returned to 5 mM KCl the resting potential went back to its original level with a half time of 17 min. This repolarization was blocked by 5 mM BaCl 2, a blocker of the inward rectifier K channel. On the other hand, 0.1 mM apamin and 0.02 mM glibenclamide which block the Ca-dependent and ATP sensitive K channels, respectively, and 0.1 mM 9-AC a blocker of the Cl channel did not affect the repolarization. 5 mM barium decreased the K conductance measured under current-clamp conditions in diaphragm muscle fibers. The possible role of the inward rectifier system in the repolarization following return to normal [K] 0 is discussed.

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