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Genetic modifiers of non-alcoholic fatty liver disease progression.

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
0925-4439
Publisher
Elsevier
Publication Date
Volume
1812
Issue
11
Identifiers
DOI: 10.1016/j.bbadis.2011.07.017
Disciplines
  • Biology
  • Medicine

Abstract

Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common cause of liver dysfunction worldwide. However, whilst the majority of individuals who exhibit features of the metabolic syndrome including obesity and insulin resistance will develop steatosis, only a minority progress to steatohepatitis, fibrosis and cirrhosis. Subtle inter-patient genetic variations and environment interact to determine disease phenotype and influence progression. A decade after the sequencing of the human genome, the comprehensive study of genomic variation offers new insights into the modifier genes, pathogenic mechanisms and is beginning to suggest novel therapeutic targets. We review the current status of the field with particular focus on advances from recent genome-wide association studies.

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