Affordable Access

Publisher Website

Emerging roles of Cdk8 in cell cycle control

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
1874-9399
Publisher
Elsevier
Volume
1829
Issue
9
Identifiers
DOI: 10.1016/j.bbagrm.2013.04.010
Keywords
  • Wnt/β-Catenin Signaling
  • Mitosis
  • Stem Cells
  • Differentiation
  • Protein Stability
  • Mediator
Disciplines
  • Biology

Abstract

Abstract Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.

There are no comments yet on this publication. Be the first to share your thoughts.