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Ebselen effects on MPTP-induced neurotoxicity

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
1118
Issue
1
Identifiers
DOI: 10.1016/j.brainres.2006.08.020
Keywords
  • Ebselen
  • Mptp
  • Monoamine Oxidase
  • Neuroprotection
  • Sh-Sy5Y Cell

Abstract

Abstract We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10–100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.

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