Publisher Summary This chapter describes several experiments that have isolated and characterized pluripotent progenitor cells from amniotic fluid. It also provides various lineages that these cells have been differentiated into and directions in this area of research. The ability to isolate the progenitor cells during gestation may also be advantageous for babies born with congenital malformations. Furthermore, the progenitor cells can be cryopreserved for future self-use. When compared with embryonic stem cells, the progenitor cells isolated from amniotic fluid have many similarities: They can differentiate into all three germ layers; they express common markers; they preserve their telomere length. However, progenitor cells isolated from amniotic fluid also have considerable advantages.