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A new approach to the characterization of the B and A forms of DNA by I.R. spectroscopy

Elsevier Inc.
Publication Date
DOI: 10.1016/0006-291x(73)91226-6
  • Biology
  • Physics


Abstract The RNA conformational changes of B, A and C forms are reflected in the infrared absorption spectra in the region of 800 cm −1 to 900 cm −1 and allow one to investigate unoriented samples. The transition to the A form is characterized by the appearence of bands at about 870 cm −1 and at 813 cm −1 whereas the B and the C forms exhibit a band at 837 cm −1, these bands undoubtedly arise from phosphate diester stretching vibrations and yield information about backbone conformation. The presence of these infrared bands provides a criterion for testing the simultaneous presence of two coexisting forms of DNA. It represents a useful method for structural studies of nucleic acid complexes such as protein-DNA for which it is difficult to obtain orientation.

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