Summary A case of sickle-cell anemia in a newborn Negro female is reported. Previous to this report the earliest reported case occurred in a 19-day-old Negro infant. Jaundice, epistaxis, and familial history prompted the suspicion of a sickle-cell crisis in this patient. Both parents showed evidence of sicklemia only, and the patient's sister, the only other living sibling, is being treated for sickle-cell anemia. The diagnosis was established by laboratory means, and other causes of hemolytic anemia excluded. Response to therapy with whole blood transfusions was gratifying. Weight gain was progressive and adequate. The need for a guarded prognosis is necessitated by the patient's age and the early onset of sickle-cell anemia.