Affordable Access

Publisher Website

Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney

Archives of Medical Science
Termedia Sp. z.o.o.
Publication Date
DOI: 10.5114/aoms.2011.22069
  • Basic Research
  • Chemistry


Introduction Transforming growth factor-β1 (TGF-β1) has a crucial role in collagen synthesis and fibrosis. TGF-β1 can be antagonized and/or reduced by the action of certain agents. We propose to identify the role of decorin in treatment of tubular and interstitial fibrosis and in the inhibition of TGF-β1 in an acute ischaemic kidney. Material and methods We grouped 34 female Sprague Dawley type rats into 3 groups as 9 sham, 9 ischaemia-reperfusion (I/R) and 16 I/R + decorin respectively. The rats in the I/R + decorin group had decorin administered intraperitoneally at the dose of 0.1 mg/kg for 9 days after reperfusion. After 9 days, all the rats in the 3 groups were unilaterally nephrectomized. The TGF-β1 level was measured immunohistochemically in the nephrectomized material. Results The TGF-β1 level was lower in the I/R + decorin group. Evaluation of apoptotic activity level by caspase staining showed a statistically significant difference between the 3 groups. The number of caspase stained cells was lower in the I/R + decorin group. The amount of collagen in interstitial tissue was higher in the I/R group than in the I/R + decorin group, but this difference was not statistically significant. Conclusions We found that the TGF-β1 level – the so-called initiator of fibrotic activity – and apoptotic activity were low in the I/R + decorin group. Additional studies must be performed to understand the role of decorin in inhibition of TGF-β1 and to assess decorin’s routine use in acute renal ischaemia.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Protective effects of dexrazoxane against acute is...

on Canadian Journal of Physiology... September 2012

Protective effect of curcumin on acute lung injury...

on Toxicology and industrial heal... August 2013

Protective effects of Tribulus terrestris L extrac...

on Iranian journal of kidney dise... July 2014

Protective antioxidant effects of carvedilol in a...

on The Journal of international m... 2005
More articles like this..