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Synthesis of potent sigma-1 receptor ligands via fragmentation of dextromethorphan

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
14
Issue
7
Identifiers
DOI: 10.1016/j.bmcl.2003.12.105

Abstract

Abstract Treatment of dextromethorphan 1 with various alkylating agents followed by base treatment led to Hoffman-type elimination reactions to produce a series of tricyclic derivatives, 6. These derivatives were characterized in vitro as sigma-1 receptor ligands.

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