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The effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor agonist and antagonists on hypothalamic neurones in the anaesthetized rat which respond to changes in scrotal skin temperature

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
201
Issue
3
Identifiers
DOI: 10.1016/0304-3940(95)12199-4
Keywords
  • Temperature
  • Hypothalamus
  • Excitatory Amino Acids
  • Scrotal Skin
  • N-Methyl-D-Aspartate (Nmda)
  • Non-Nmda

Abstract

Abstract There are neurons in the pre-optic anterior hypothalamus of the anaesthetised rat which respond to changes in scrotal skin temperature. Neuronal firing rate can be increased by raising the scrotal skin temperature above 36°C, and also by ionophoretic application of either N-methyl- d-aspartate (NMDA) or α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) (a non-NMDA receptor agonist). The increase in neuronal firing evoked by thermal stimulation was prevented or diminished by concurrent application of either d-2-amino-5-phosphonopentanoic acid (D-AP5) (an NMDA receptor antagonist) or 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo( F)quinoxaline (a non-NMDA receptor antagonist) at doses which were sufficient to abolish or significantly diminish the effect of the specific agonist. It is probable that both NMDA and non-NMDA receptors are involved in the scrotal thermoafferent pathway in the rat.

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