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A one-pot synthesis of 3-methyl-5-aryl-4H-pyrrolo[2,3-d]-isoxazoles

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
47
Issue
28
Identifiers
DOI: 10.1016/j.tetlet.2006.04.145
Keywords
  • Sharpless Epoxidation
  • Epoxide Ring-Opening
  • Cyclization
  • Dehydration
  • One-Pot Synthesis

Abstract

Abstract Sharpless epoxidation of 4-amino-3-methyl-5-styrylisoxazoles 1 resulted in the formation of 3-methyl-5-aryl-4 H-pyrrolo[2,3- d]-isoxazoles 4 in a one-step reaction. The reaction initially involves epoxide formation, followed by ring-opening and cyclization. Finally dehydration leads to the title compounds. The pyrrolo[2,3- d]-isoxazoles 4 were also synthesized via an alternative procedure.

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