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P68 RNA Helicase Is A Nucleocytoplasm Shuttling Protein

Authors
Journal
Cell Research
1001-0602
Publisher
Nature Publishing Group
Publication Date
Volume
19
Issue
12
Identifiers
DOI: 10.1038/cr.2009.113
Keywords
  • Article
Disciplines
  • Biology

Abstract

P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. In consistence with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus. However, recent experiments demonstrate a transient cytoplasmic localization of the protein. We report here that p68 shuttles between the nucleus and the cytoplasm. The nucleocytoplasmic shuttling of p68 is mediated by two nuclear localization signal (NLS) and two nuclear exporting signal (NES) sequence elements. Our experiments reveal that p68 shuttles via a classical RanGTPase dependent pathway.

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