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Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

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The helicity of the (SSS)-Delta enantiomer of a terbium and europium(III) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Lambda complexes, thereby defining a unique chiroptical probe of albumin binding.

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