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Effective detergent/lipid ratios in the solubilization of phosphatidylcholine vesicles by Triton X-100

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
302
Issue
2
Identifiers
DOI: 10.1016/0014-5793(92)80424-f
Keywords
  • Surfactant
  • Detergent
  • Membrane Solubilization
  • Liposome
  • Triton X-100

Abstract

Abstract Effective detergent:lipid ratios (i.e. molar ratios in the mixed aggregates, vesicles or micelles) have been estimated for the solubilization of phosphatidylcholine vesicles by Triton X-100. Effective molar ratios are given for both the onset and the completion of bilayer solubilization; small unilamellar, large unilamellar and multilamellar vesicles have been used. Effective detergent:lipid ratios are independent of phospholipid concentration, and their use allows a deeper understanding of membrane-surfactant interactions.

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