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Progesterone and 20α-hydroxyprogesterone stimulate the in vitro release of GnRH by the isolated mediobasal hypothalamus

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
32
Issue
13
Identifiers
DOI: 10.1016/0024-3205(83)90919-0

Abstract

Abstract An in vitro perifusion system was used to investigate the effect of progesterone (P 4) and 20α-hydroxyprogesterone (20α-OHP) on the release of GnRH from isolated hypothalamic tissue of the adult ovariectomized estradiol-17β primed rat. Pulse delivery of P 4 stimulated GnRH release not only from the isolated mediobasal hypothalamus-anterior hypothalamus-preoptic area (MBH-AHPOA) complex but also from the MBH alone. Release of GnRH from the MBH was also increased by 20α-OHP. These results suggest that the in vivo increase of circulating P 4 or 20α-OHP associated with the initiation of the preovulatory LH surge may play a role in regulating the timing or amplitude of this surge by directly stimulating the release of GnRH from the MBH.

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