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Cytotoxic dinuclear titanium-salan complexes: Structural and biological characterization

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Publication Date
Volume
106
Issue
1
Identifiers
DOI: 10.1016/j.jinorgbio.2011.08.029
Keywords
  • Dinuclear Complexes
  • Titanium Salan Complexes
  • Hydrolysis
  • Antitumor Agents
  • Cytotoxicity

Abstract

Graphical abstract Controlled hydrolysis of donor-substituted titanium (IV) salan complexes led to the formation of well-defined dinuclear complexes with cytotoxicities in the low micro-molar region. Highlights ► Donor substituted Ti(IV)salan complexes are cytotoxic in human cancer cell lines. ► Structurally characterized dinuclear complexes form upon fast hydrolysis. ►μ 2-oxo bridged dinuclear complexes show enhanced cytotoxicity. ► First identified cytotoxic intermediates from Ti(IV)salan hydrolysis. ► Partial hydrolysis acts as activating mechanism.

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