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Gestational diabetes mellitus management with oral hypoglycemic agents

Authors
Journal
Seminars in Perinatology
0146-0005
Publisher
Elsevier - WB Saunders
Identifiers
DOI: 10.1053/j.semperi.2014.08.012
Keywords
  • Gestational Diabetes
  • Glyburide
  • Metformin
  • Hypoglycemic Agents
  • Pregnancy Outcome
Disciplines
  • Medicine
  • Pharmacology

Abstract

Abstract Oral hypoglycemic agents such as glyburide (second-generation sulfonylurea) and metformin (biguanide) are attractive alternatives to insulin due to lower cost, ease of administration, and better patient adherence. The majority of evidence from retrospective and prospective studies suggests comparable efficacy and safety of oral hypoglycemic agents such as glyburide and metformin as compared to insulin when used in the treatment of women with gestational diabetes mellitus (GDM). Glyburide and metformin have altered pharmacokinetics during pregnancy and both agents cross the placenta. In this article, we review the efficacy, safety, and dosage of oral hypoglycemic agents for the treatment of gestational diabetes mellitus. Additional research is needed to evaluate optimal dosage for glyburide and metformin during pregnancy. Comparative studies evaluating the effects of glyburide and metformin on long-term maternal and fetal outcomes are also needed.

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