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Convenient syntheses of dihydropyrrolo[2′,1′:3,4]pyrazino- and dihydropyrrolo[2′,1′:3,4][1,4]diazepino-[2,1-a]isoindolones

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
15
Identifiers
DOI: 10.1016/s0040-4039(02)00350-7

Abstract

Abstract Dihydropyrrolo[2′,1′:3,4]pyrazino[2,1- a]isoindolones 10a– 10c were obtained in 76–81% yields by the reaction of 2-(1 H-pyrrol-1-yl)ethylamine 8 with 2-formylbenzoic acids 9a , 9b or 2-acetylbenzoic acid 9c via N-acyliminium cation aromatic cyclizations. Similarly, dihydropyrrolo[2′,1′:3,4][1,4]diazepino[2,1- a]isoindolones 12a , 12b were prepared in one-pot reactions from 3-(1 H-pyrrol-1-yl)propylamine 11 and 2-formylbenzoic acids 9a , 9b .

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