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Replacement of the phosphodiester linkage in oligonucleotides: Comparison of two structural amide isomers

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
4
Issue
7
Identifiers
DOI: 10.1016/s0960-894x(01)80254-7

Abstract

Abstract The two structural amide isomers 2 and 3 as backbone replacement in oligonucleotides lead to very similar results for the binding affinities (T m) of the duplexes formed with their complementary RNA strands.

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