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Selectivity tunable divergent synthesis of 1,4- and 1,2-dihydropyridines via three-component reactions

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
70
Issue
43
Identifiers
DOI: 10.1016/j.tet.2014.09.002
Keywords
  • Cascade Reaction
  • Heterocycle
  • 1
  • 4-Dihydropyridine
  • 1
  • 2-Dihydropyridine
  • Regioselective

Abstract

Abstract The tunable three-component reactions of enals, electron deficient alkynes, and primary amines have been achieved for selective synthesis of 1,4- and 1,2-dihydropyridines. The selectivity has been found to be in close relation to the property of the amine component.

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