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Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts

Authors
Journal
Journal of the Autonomic Nervous System
0165-1838
Publisher
Elsevier
Publication Date
Volume
65
Issue
1
Identifiers
DOI: 10.1016/s0165-1838(97)00034-9
Keywords
  • Carbon Monoxide
  • Enteric Nervous System
  • Heme Oxygenase
  • Nitric Oxide Synthase
  • Non-Adrenergic
  • Non-Cholinergic
  • Vasoactive Intestinal Peptide
Disciplines
  • Biology

Abstract

Abstract Carbon monoxide (CO), produced by haem oxygenase (HO), has been suggested as a messenger molecule in the central and peripheral nervous systems. In the present study, we have investigated the occurrence of the two isoforms of HO, HO-2 and HO-1 in the canine and feline gastrointestinal tracts, including the small and large intestine and the gastrointestinal sphincters. An abundance of nerve cell bodies that contained immunoreactivity for HO-2 was found in the submucosal and myenteric plexuses. HO-2 immunoreactivity was frequently co-localized with nitric oxide synthase (NOS) or vasoactive intestinal peptide (VIP) immunoreactivities and was also observed in some nerve fibres, certain non-neuronal cells dispersed among smooth muscle bundles, and in vascular endothelium. The antiserum against HO-1 revealed immunoreactivity in nerve cell bodies in the enteric plexuses, in nerve fibres and in non-neuronal cells in the smooth muscle layers. Some of the nerve structures were also NOS- or VIP-immunoreactive. These results demonstrate the presence of HO isoenzymes in nerves and other structures of the canine and feline gastrointestinal tracts and support the view that CO may have a role as a messenger molecule in the enteric nervous system.

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