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Impaired hippocampal long-term potentiation in melatonin MT2receptor-deficient mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
393
Issue
1
Identifiers
DOI: 10.1016/j.neulet.2005.09.040
Keywords
  • Memory
  • Learning
  • Alzheimer'S Disease
  • Synaptic Plasticity
  • Pineal
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT 2 receptors (MT 2 knockouts) to investigate the role of these receptors in synaptic plasticity and learning-dependent behavior. In field CA1 of hippocampal slices from wild-type mice, theta burst stimulation induced robust and stable long-term potentiation that was smaller and decremental in slices from MT 2 knockouts. Tested in an elevated plus-maze on two consecutive days, wild-type mice showed shorter transfer latencies to enter a closed arm on the second day; this experience-dependent behavior did not occur in MT 2 knockouts. These results suggest that MT 2 receptors participate in hippocampal synaptic plasticity and in memory processes.

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