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Induction of Mucosal B-Cell Memory by Intramuscular Inoculation of Mice with Rotavirus

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Viral Pathogenesis And Immunity

Abstract

We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.

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