Affordable Access

Publisher Website

Does Chemotherapy Cause Viral Relapse in Cancer Patients With Hepatitis C Infection Successfully Treated With Antivirals?

Authors
Journal
Clinical Gastroenterology and Hepatology
1542-3565
Publisher
Elsevier
Volume
12
Issue
6
Identifiers
DOI: 10.1016/j.cgh.2013.10.034
Keywords
  • Hepatitis C Virus
  • Svr
  • Chemotherapy
  • Interferon
  • Ribavirin
Disciplines
  • Biology
  • Medicine

Abstract

Authors have reported conflicting results on the persistence of hepatitis C virus (HCV) infection in patients having sustained virologic response (SVR) to treatment. Therefore, we sought to determine whether chemotherapy leads to viral relapse in 30 HCV-infected patients who had SVR before cancer diagnosis. Half of them had hematologic malignancies. Most (60%) received HCV therapy with interferon and ribavirin. Chemotherapy was started at a median of 72 months after SVR and included rituximab (27%), cyclophosphamide (23%), cisplatin (17%), or corticosteroids (37%). No patient had post-SVR viral relapse. Therapeutically induced resolution of HCV appears to be permanent and not affected by chemotherapy.

There are no comments yet on this publication. Be the first to share your thoughts.