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Alkylxanthines as research tools

Authors
Journal
Journal of the Autonomic Nervous System
0165-1838
Publisher
Elsevier
Publication Date
Volume
81
Identifiers
DOI: 10.1016/s0165-1838(00)00110-7
Keywords
  • Caffeine
  • Methylxanthines
  • Pharmacological Effects
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract (1) The methylxanthine caffeine has many pharmacological effects, most of which can be linked to blockade of adenosine receptors, inhibition of phosphodiesterases, and augmentation of calcium-dependent release of calcium from intracellular stores. (2) A variety of xanthines have been developed as potent and/or selective antagonists for adenosine receptors. (3) Several xanthines have been developed that are more potent and more selective inhibitors of cyclic nucleotide phosphodiesterase than caffeine or theophylline. (4) Caffeine remains the xanthine of choice for activation of intracellular calcium-sensitive calcium release channels although millimolar concentrations are required, which can have effects on other aspects of calcium regulation.

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