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Induced PKU in rats: Effects of age and melatonin treatment

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1016/0091-3057(77)90196-4
Keywords
  • Phenylketonuria
  • Hyperphenylalaninemia
  • P-Chlorophenylalanine
  • Melatonin
  • Phenylalanine
  • Serotonin
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Newborn rats injected on Days 1–8 of life with L-phenylalanine (2 g/kg) and p-chlorophenylalanine (80 mg/kg) displayed biochemical symptoms analogous to human phenylketonuria (PKU) and maze learning impairments. The behavioral effects were less evident in rats treated on Days 9–16 or 17–24. None of the symptoms observed were alleviated by simultaneous administration of melatonin (10 mg/kg/day).

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