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Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

Authors
Publisher
American Society for Microbiology
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Keywords
  • Opportunistic Pathogenic Bacteria Can Engage In Biofilm-Based Infections That Evade Immune Responses
  • Because Conventional Antimicrobials Cannot Efficiently Eradicate Biofilms
  • There Is An Urgent Need To Develop Alternative Measures To Combat Biofilm Infections
  • It Has Recently Been Established That The Secondary Messenger Cyclic Diguanosine Monophosphate (C-Di
  • In The Present Study We Investigated Whether Manipulation Of The C-Di-Gmp Level In Bacteria Potentia
  • We Constructed A Pseudomonas Aeruginosa Strain In Which A Reduction In The C-Di-Gmp Level Can Be Ach
  • Initial Experiments Showed That Induction Of Yhjh Expression Led To Dispersal Of The Majority Of The
  • Aeruginosa Biofilms
  • Subsequently
  • We Demonstrated That P
  • Aeruginosa Biofilms Growing On Silicone Implants
  • Located In The Peritoneal Cavity Of Mice
  • Dispersed After Induction Of The Yhjh Protein
  • Bacteria Accumulated Temporarily In The Spleen After Induction Of Biofilm Dispersal
  • But The Mice Tolerated The Dispersed Bacteria Well
  • The Present Work Provides Proof Of The Concept That Modulation Of The C-Di-Gmp Level In Bacteria Is

Abstract

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria - DTU Orbit (17/05/14) Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria - DTU Orbit (17/05/14) Christensen, LD, van Gennip, M, Rybtke, MT, Wu, H, Chiang, W-C, Alhede, M, Høiby, N, Nielsen, TE, Givskov, M & Tolker-Nielsen, T 2013, 'Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria' Infection and Immunity, vol 81, no. 8, pp. 202705-2713., 10.1128/IAI.00332-13

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