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Systemic features of immune recognition in the gut

Authors
Journal
Microbes and Infection
1286-4579
Publisher
Elsevier
Publication Date
Volume
13
Identifiers
DOI: 10.1016/j.micinf.2011.06.011
Keywords
  • Immune Recognition
  • Systems Immunology
  • Pathogen
  • Pathogen-Associated Molecular Pattern
Disciplines
  • Biology

Abstract

Abstract The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

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